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21c Museum Hotel St Louis

St. Louis • Downtown • SPLURGE

avg. $407 / night

Includes $21 / night in cash back

Cash back is redeemable via Virtual Visa, Venmo, or bank transfer starting 24-48 hours after check-out

ALL - Accor property

Exclusive PressBeyond Benefits

Get to where you see yourself

Ultra-clean, global, hand-picked hotel curation & imagery designed to help you visualize enticing environments and the elevated social experiences they create

Cash back

5% cash back on all completed stays (redeemable via Virtual Visa, Venmo, or bank transfer starting 24-48 hours after check-out)

Credit card points

Credit and debit card charges are processed directly by the hotel (i.e. not PressBeyond), meaning that any travel-specific credit card points or incentives that you normally get as a cardholder for direct hotel bookings are preserved

Hotel loyalty points

Points accrual and status eligibility with major hotel loyalty programs: Marriott Bonvoy, Hilton Honors, World of Hyatt, and others

Free breakfast

Breakfast-included rate options available

Room upgrades

Complimentary room upgrades (subject to property availability)

Extend your stay

Early check-in and late check-out (subject to property availability)

Location

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PB hotel design editorial

Erected in 1924 as the St. Louis YMCA, the twelve-storey Romanesque Revival tower on Locust Street carries its origins with unusual candor — the words Swim For Life still set into the pool floor in mosaic tile, the original amber and ochre tilework lining walls that predate the city's mid-century exodus by decades. 21c Museum Hotel St. Louis, which took over the building in 2017, made the right call in leaving that pool exactly as found: it remains one of the more quietly moving rooms in American hospitality, a preserved social institution repurposed without sentimentality. The conversion, designed with interiors by Deborah Berke Partners — the architecture practice behind the entire 21c chain — layers contemporary art programming over the building's civic bones with a calibrated irreverence. Guestrooms pair channeled upholstered headboards and herringbone-patterned carpets in warm taupe with mid-century-inflected brass-and-black pendant fixtures and bright accent chairs in burnt orange, while larger suites introduce moss-green velvet sectionals and sculptural art objects — a oversized red penguin, the brand's recurring mascot, stationed with deadpan confidence beside the bed. The bar and restaurant space is the boldest gesture: double-height arched windows fitted with dramatically curved wooden reveals frame a marble-topped oval bar clad in deep burgundy tile, large-scale figurative paintings covering the remaining wall plane. The exterior's limestone base and corbelled brick cornice, dramatically illuminated at dusk, make clear that the building was always worth saving.

Travel notes

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About

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Amenities

Pool

Internet

Suites

Room service

Free Internet

Wheelchair Access

Restaurant

Bar/Lounge

Pets Allowed

Wifi

21c Museum Hotel St Louis Reviews

191 reviews

"Hallways and room felt dirty. Bathroom appears to not be cleaned. Refrigerator was in room but unplugged, phones in room not working and had to call front desk from mobile to have them bring a tv remote to room because there wasn’t one in the room. Most disappointing was valet wrecked my truck, apologized and accepted responsibility on the sidewalk as they pulled my truck up, they filed a claim through PMC their “Parking Management Company” and PMC denied the claim stating “ Our management team conducted a thorough inspection of the property, including the driving path and the vehicle parking area, and we were unable to identify any factors that could have contributed to the damage. There was no damage to any other vehicles or fixed objects that could account for the reported damage.” Would strongly encourage you to stay somewhere else."

A Tripadvisor traveler review

Apr 17, 2026

"Kielan at valet was great. He greeted us and was friendly and informative."

A Tripadvisor traveler review

Apr 17, 2026

"Kilen is so kind (I'm sorry for the spelling!!) - soon as we got back from dinner, this man saved the day and had an umbrella ready for my lady when she got out of the car in the rain. Thank you again for taking care of us!"

A Tripadvisor traveler review

Apr 15, 2026

"Visited Hotel 21C to experience their art exhibit. Had an incredible tour with Angie Villa. The hotel is gorgeous, the exhibit was incredible! Ate evening meal in Idol Wolf, with seven other people. Everyone only had great things to say about their meals."

A Tripadvisor traveler review

Apr 13, 2026

"One of the coolest hotels I've ever stayed at. The lobby is beautiful, with several sitting areas and two restaurants. When we were there the art gallery exhibit was called The Future is Female, with remarkable pieces created from all sorts of media -- it's like a real museum that you can go to for free. The best part for us was the vintage tiled swimming pool, hot tub, sauna, and steam room in the old YMCA space. Super relaxing way to spend a long winter afternoon."

A Tripadvisor traveler review

Feb 12, 2026

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21c Museum Hotel St Louis | Best Design-Driven Stays in St. Louis