1/5

21c Museum Hotel St Louis

Name: 21c Museum Hotel St Louis
Address: 1528 Locust St, St. Louis, MO 63103, St. Louis, United States
Price range: $$$ ($407/night and up)
Rating: 4.3

5% cash back when you book with PressBeyond

21c Museum Hotel St Louis — Standardized Hotel Image Sequence #1 — Exterior — Exterior · 21c Museum Hotel St Louis · PressBeyond hotel series

21c Museum Hotel St Louis — Standardized Hotel Image Sequence #2 — Primary Guest Room — Primary Guest Room · 21c Museum Hotel St Louis · PressBeyond hotel series

21c Museum Hotel St Louis — Standardized Hotel Image Sequence #3 — Primary Common Area — Primary Common Area · 21c Museum Hotel St Louis · PressBeyond hotel series

21c Museum Hotel St Louis

St. Louis • Downtown • SPLURGE

avg. $407 / night

Includes $21 / night in cash back

Cash back is redeemable via Virtual Visa, Venmo, or bank transfer starting 24-48 hours after check-out

ALL - Accor property

Exclusive PressBeyond Benefits

Get to where you see yourself

Ultra-clean, global, hand-picked hotel curation & imagery designed to help you visualize enticing environments and the elevated social experiences they create

Cash back

5% cash back on all completed stays (redeemable via Virtual Visa, Venmo, or bank transfer starting 24-48 hours after check-out)

Credit card points

Credit and debit card charges are processed directly by the hotel (i.e. not PressBeyond), meaning that any travel-specific credit card points or incentives that you normally get as a cardholder for direct hotel bookings are preserved

Hotel loyalty points

Points accrual and status eligibility with major hotel loyalty programs: Marriott Bonvoy, Hilton Honors, World of Hyatt, and others

Free breakfast

Breakfast-included rate options available

Room upgrades

Complimentary room upgrades (subject to property availability)

Extend your stay

Early check-in and late check-out (subject to property availability)

Location

Loading map...

At a glance

A 1924 YMCA conversion with preserved original pool, Deborah Berke interiors, and integrated contemporary art programming.

Best for: Art collectors and architecture enthusiasts

Highlights:

1924 Romanesque Revival YMCA with original pool and mosaic tilework
Interiors by Deborah Berke Partners with contemporary art throughout
Double-height bar with curved wooden reveals and figurative paintings

Civic-modernart-forward

PB hotel design editorial

Erected in 1924 as the St. Louis YMCA, the twelve-storey Romanesque Revival tower on Locust Street carries its origins with unusual candor — the words Swim For Life still set into the pool floor in mosaic tile, the original amber and ochre tilework lining walls that predate the city's mid-century exodus by decades. 21c Museum Hotel St. Louis, which took over the building in 2017, made the right call in leaving that pool exactly as found: it remains one of the more quietly moving rooms in American hospitality, a preserved social institution repurposed without sentimentality. The conversion, designed with interiors by Deborah Berke Partners — the architecture practice behind the entire 21c chain — layers contemporary art programming over the building's civic bones with a calibrated irreverence. Guestrooms pair channeled upholstered headboards and herringbone-patterned carpets in warm taupe with mid-century-inflected brass-and-black pendant fixtures and bright accent chairs in burnt orange, while larger suites introduce moss-green velvet sectionals and sculptural art objects — a oversized red penguin, the brand's recurring mascot, stationed with deadpan confidence beside the bed. The bar and restaurant space is the boldest gesture: double-height arched windows fitted with dramatically curved wooden reveals frame a marble-topped oval bar clad in deep burgundy tile, large-scale figurative paintings covering the remaining wall plane. The exterior's limestone base and corbelled brick cornice, dramatically illuminated at dusk, make clear that the building was always worth saving.

Travel notes

No travel notes provided yet.

About

No description provided yet.

Amenities

Pool

Internet

Suites

Room service

Free Internet

Wheelchair Access

Restaurant

Bar/Lounge

Pets Allowed

Wifi

21c Museum Hotel St Louis Reviews

202 reviews

"I absolutely loved the room & staff during my recent stay. The room was elegant and beautiful. The late night staff was wonderful!! Extremely kind, funny and so helpful!! Thank you, to all the staff and a special shout out to Miss V, Rose & Brandy. You ladies are the absolute best!!"

A Tripadvisor traveler review

Jul 28, 2026

"The Front Desk is the star of the show. Had no issues fulfilling all of our requests and did so with no issues. I’d like to thank Mae as she has been exceptional during our 2 night stay"

A Tripadvisor traveler review

Jul 28, 2026

"Did not stay overnight at this beautiful boutique hotel, we had lunch at the Idol Wolf and viewed the art gallery on the second floor. This historic building was originally a YMCA which 21c has repurposed as a artsy boutique hotel right next door to the historic Campbell House. We enjoyed wine and beer. Then we had a great Spanish Caesar Salad and a cheeseburger with fries. Fries were fabulous, burger was okay-bun was soggy on the bottom. Server was most solicitous, checking on us several times. You’re able to carry your drinks up to the second floor to the art gallery. The exhibits change yearly. The stairs up to the second floor are incredible; bold pattern of flowers and animals on both the carpeting and wallpaper. They were commissioned to match. And the sconces are also animal themed. Quite impressive staircase and multiple people taking photos on the stairs. There are multiple small galleries upstairs with a variety of art styles from tapestries to photos to paintings. The gymnasium from the YMCA has been turned into a lovely event space with art lining the walls and refurbished gym flooring."

A Tripadvisor traveler review

Jul 06, 2026

"Ms. V is a phenomenal front desk attendant. She’s very attentive as she assisted me with a reservation at the last minute! Her calming and attentive manner is what is needed in her position and she possesses both! The hotel is beautiful and Ms. V made my stay a very pleasant and welcoming one. Thank you for knowing how to select great and welcoming front desk staff like Ms. V."

A Tripadvisor traveler review

Jul 04, 2026

"Vanecia at the front desk provided an exceptional experience with her kind- hearted spirit and unreasonable hospitality efforts to ensure my spouse and I had great time during our stay here at the 21c museum hotel."

A Tripadvisor traveler review

Jun 26, 2026

Guest photos

+54